Computational Biology Labs
@ IRIBHM Jacques E. Dumont

Selective sweep probabilities in spatially expanding populations  — 2026  — Nature Communications  (Alexander Stein)
Abstract 3534: Forecasting oncogene amplification and tumor suppressor deletion  — 2026  — Cancer Research  (Maxime Tarabichi)
An atlas of human histological diversity  — 2026  — bioRxiv (Cold Spring Harbor Laboratory) preprint  (Diego Serra, Hugo Mantion, Maxime Tarabichi, Vincent Detours, Zhao Zhang)
Chromosomal instability shapes spatial and temporal phenotypic diversity in a malignant peripheral nerve sheath tumour  — 2026  — bioRxiv (Cold Spring Harbor Laboratory) preprint  (Alexander Stein, Maxime Tarabichi)
Integrating Methylomic and Fragmentomic Profiling in Soft Tissue Sarcoma: Unravelling Novel Epigenetic Signatures  — 2026  — European Journal of Surgical Oncology  (Maxime Tarabichi)
Linking somatic mutations in cancer to the electronic properties of DNA  — 2026  — BMC Genomics  (Benoit de Witte, Maxime Tarabichi)
PRECISE: A Prognostic Thyrocyte-Derived Gene Signature for Papillary Thyroid Carcinoma  — 2026  — Clinical Cancer Research  (Maxime Tarabichi)
Parent-of-origin phasing of somatic mutations shows equal mutation burden between parental genomes in human cancers  — 2026  — bioRxiv (Cold Spring Harbor Laboratory) preprint  (Mathieu Parmentier, Maxime Lefèbvre, Maxime Tarabichi, Vincent Detours)
Processed data for "Chromosomal instability shapes spatial and temporal phenotypic diversity in a malignant peripheral nerve sheath tumour"  — 2026  — Zenodo (CERN European Organization for Nuclear Research) preprint  (Alexander Stein, Maxime Tarabichi)
Summary tables for Linking somatic mutations in cancer to the electronic properties of DNA  — 2026  — Zenodo (CERN European Organization for Nuclear Research) preprint  (Benoit de Witte, Maxime Tarabichi)
alexsteininfo/Sweeps-In-Space: Code at the time of final paper submission  — 2026  — Zenodo (CERN European Organization for Nuclear Research) preprint  (Alexander Stein)
Public Goods Games in Disease Evolution and Spread  — 2025  — Dynamic Games and Applications  (Alexander Stein)
A Luminal–Basal Stratification of the Native Human Pancreatic Duct is Differentially Represented in Pancreatic Cancers  — 2025  — bioRxiv (Cold Spring Harbor Laboratory) preprint  (Oier Azurmendi)
Detection of Circulating Tumour DNA (ctDNA) with ddPCR and NGS in Liposarcoma  — 2025  — European Journal of Surgical Oncology  (Maxime Tarabichi)
Forecasting oncogene amplification and tumour suppressor deletion  — 2025  — bioRxiv (Cold Spring Harbor Laboratory) preprint  (Maxime Tarabichi)
Systematic analysis of A-to-I RNA editing upon release of ADAR from the nucleolus  — 2025  — RNA Biology  (Ruben Lattuca, Vincent Detours)
CLIP2: a novel functional player in AQP5 trafficking dynamics and implications for Sjögren’s disease  — 2025  — Cell Communication and Signaling  (Maxime Tarabichi)
Glycation Stress–Driven Transcriptomic Signature Predicts Survival Benefit from Adjuvant Gemcitabine in Resectable Pancreatic Cancer  — 2025  — bioRxiv (Cold Spring Harbor Laboratory) preprint  (Oier Azurmendi, Vincent Detours)
RASSF1A Methylation and Survival Outcome in Retroperitoneal Leiomyosarcoma  — 2025  — European Journal of Surgical Oncology  (Maxime Tarabichi)
Aneuploidy and complex genomic rearrangements in cancer evolution  — 2024  — Nature Cancer  (Maxime Tarabichi)
The History of Chromosomal Instability in Genome-Doubled Tumors  — 2024  — Cancer Discovery  (Maxime Tarabichi)
Genomic evolution shapes prostate cancer disease type  — 2024  — Cell Genomics  (Maxime Tarabichi)
Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction  — 2024  — Nature Biotechnology  (Maxime Tarabichi)
Reconstructing oral cavity tumor evolution through brush biopsy  — 2024  — Scientific Reports  (Maxime Tarabichi)
Subclonal mutation load predicts survival and response to immunotherapy in cancers with low to moderate tumor mutation burden  — 2024  — bioRxiv (Cold Spring Harbor Laboratory) preprint  (Maxime Tarabichi)
Favorable histo-molecular remodeling of pancreatic ductal adenocarcinoma after Total Neoadjuvant Therapy including Stereotactic Body Radiotherapy  — 2024  — bioRxiv (Cold Spring Harbor Laboratory) preprint  (Oier Azurmendi, Vincent Detours)
Idiosyncratic and generic single nuclei and spatial transcriptional patterns in papillary and anaplastic thyroid cancers  — 2024  — bioRxiv (Cold Spring Harbor Laboratory) preprint  (Maxime Tarabichi, Vincent Detours)
Abstract 1765: The genetic landscape of head and neck cancer using brush biopsy  — 2024  — Cancer Research  (Maxime Tarabichi)
Abstract 4337: Illuminating the complex rearrangement landscape of sarcoma  — 2024  — Cancer Research  (Maxime Tarabichi)
Stackelberg evolutionary game theory: how to manage evolving systems  — 2023  — Philosophical Transactions of the Royal Society B Biological Sciences  (Alexander Stein)
Author Correction: Pan-cancer analysis of whole genomes  — 2023  — Nature  (Maxime Tarabichi)
Author Correction: The evolutionary history of 2,658 cancers  — 2023  — Nature  (Maxime Tarabichi)
Author Correction: Genomic basis for RNA alterations in cancer  — 2023  — Nature  (Maxime Tarabichi)
Author Correction: The landscape of viral associations in human cancers  — 2023  — Nature Genetics  (Maxime Tarabichi)
Abstract PR008: Timing complex copy number gains in whole genome duplicated tumors  — 2023  — Cancer Research  (Maxime Tarabichi)
Author Correction: Butler enables rapid cloud-based analysis of thousands of human genomes  — 2023  — Nature Biotechnology  (Maxime Tarabichi)
Signatures of copy number alterations in human cancer  — 2022  — Nature  (Maxime Tarabichi)
A pan-cancer compendium of chromosomal instability  — 2022  — Nature  (Maxime Tarabichi)
MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution  — 2022  — Genome biology  (Maxime Tarabichi)
Author Correction: Divergent mutational processes distinguish hypoxic and normoxic tumours  — 2022  — Nature Communications  (Maxime Tarabichi)
Author Correction: Pathway and network analysis of more than 2500 whole cancer genomes  — 2022  — Nature Communications  (Maxime Tarabichi)
Crowd-sourced benchmarking of single-sample tumour subclonal reconstruction  — 2022  — bioRxiv (Cold Spring Harbor Laboratory) preprint  (Maxime Tarabichi)
Generation of human thyroid organoids from embryonic stem cells to rescue hypothyroidism  — 2022  — Endocrine Abstracts  (Vincent Detours)
Abstract 1698: Copy number diversity within and across tumor types  — 2022  — Cancer Research  (Maxime Tarabichi)
Abstract 2286: Profiling the complex rearrangement landscape of sarcoma  — 2022  — Cancer Research  (Maxime Tarabichi)
Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer  — 2022  — Nature Communications  (Maxime Tarabichi)
Author Correction: Integrative pathway enrichment analysis of multivariate omics data  — 2022  — Nature Communications  (Maxime Tarabichi)
A practical guide to cancer subclonal reconstruction from DNA sequencing  — 2021  — Nature Methods  (Maxime Tarabichi)
Therapeutic vulnerability to PARP1,2 inhibition in RB1-mutant osteosarcoma  — 2021  — Nature Communications  (Maxime Tarabichi)
Thyroid cancer under the scope of emerging technologies  — 2021  — Molecular and Cellular Endocrinology  (Maxime Tarabichi, Vincent Detours)
A pan-cancer landscape of somatic mutations in non-unique regions of the human genome  — 2021  — Nature Biotechnology  (Maxime Tarabichi)
DeCiFering the subclonal composition of tumors  — 2021  — Cell Systems  (Maxime Tarabichi)
Single-cell transcriptome analysis reveals thyrocyte diversity in the zebrafish thyroid gland  — 2021  — Yearbook of pediatric endocrinology  (Vincent Detours)
The repertoire of mutational signatures in human cancer  — 2020  — Nature  (Maxime Tarabichi)
Pan-cancer analysis of whole genomes  — 2020  — Nature  (Maxime Tarabichi)
The evolutionary history of 2,658 cancers  — 2020  — Nature  (Maxime Tarabichi)
Patterns of somatic structural variation in human cancer genomes  — 2020  — Nature  (Maxime Tarabichi)
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes  — 2020  — Nature  (Maxime Tarabichi)
Comprehensive molecular characterization of mitochondrial genomes in human cancers  — 2020  — Nature Genetics  (Maxime Tarabichi)
Genomic basis for RNA alterations in cancer  — 2020  — Nature  (Maxime Tarabichi)
The landscape of viral associations in human cancers  — 2020  — Nature Genetics  (Maxime Tarabichi)
Robust estimation of bacterial cell count from optical density  — 2020  — Communications Biology  (Mathieu Parmentier)
Integrative pathway enrichment analysis of multivariate omics data  — 2020  — Nature Communications  (Maxime Tarabichi)
Divergent mutational processes distinguish hypoxic and normoxic tumours  — 2020  — Nature Communications  (Maxime Tarabichi)
Genomic footprints of activated telomere maintenance mechanisms in cancer  — 2020  — Nature Communications  (Maxime Tarabichi)
Sex differences in oncogenic mutational processes  — 2020  — Nature Communications  (Maxime Tarabichi)
Pathway and network analysis of more than 2500 whole cancer genomes  — 2020  — Nature Communications  (Maxime Tarabichi)
A community effort to create standards for evaluating tumor subclonal reconstruction  — 2020  — Nature Biotechnology  (Maxime Tarabichi)
Transcriptional output, cell-type densities, and normalization in spatial transcriptomics  — 2020  — Journal of Molecular Cell Biology  (Vincent Detours)
Combined burden and functional impact tests for cancer driver discovery using DriverPower  — 2020  — Nature Communications  (Maxime Tarabichi)
Inferring structural variant cancer cell fraction  — 2020  — Nature Communications  (Maxime Tarabichi)
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples  — 2020  — Nature Communications  (Maxime Tarabichi)
Drivers underpinning the malignant transformation of giant cell tumour of bone  — 2020  — The Journal of Pathology  (Maxime Tarabichi)
Author Correction: Robust estimation of bacterial cell count from optical density  — 2020  — Communications Biology  (Mathieu Parmentier)
Butler enables rapid cloud-based analysis of thousands of human genomes  — 2020  — Nature Biotechnology  (Maxime Tarabichi)
Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways  — 2019  — Cancer Cell  (Maxime Tarabichi)
Dissecting the Role of Thyrotropin in the DNA Damage Response in Human Thyrocytes after 131I, γ Radiation and H2O2  — 2019  — The Journal of Clinical Endocrinology & Metabolism  (Vincent Detours)
Transcriptomic analysis of human papillary thyroid carcinoma (PTC) with and without nodal metasis  — 2019  — Signaling Pathways Project Datasets preprint  (Maxime Tarabichi)
Recurrent rearrangements of FOS and FOSB define osteoblastoma  — 2018  — Nature Communications  (Maxime Tarabichi)
Neutral tumor evolution?  — 2018  — Nature Genetics  (Maxime Tarabichi)
G enomic hotspots but few recurrent fusion genes in breast cancer  — 2018  — Genes Chromosomes and Cancer  (Vincent Detours)
Factors contributing to the resistance of the thyrocyte to hydrogen peroxide  — 2018  — Molecular and Cellular Endocrinology  (Vincent Detours)
Distinctive Desmoplastic 3D Morphology Associated With BRAFV600E in Papillary Thyroid Cancers  — 2018  — The Journal of Clinical Endocrinology & Metabolism  (Maxime Tarabichi, Vincent Detours)
Abstract 218: The evolutionary history of 2,658 cancers  — 2018  — Cancer Research  (Maxime Tarabichi)
PO-329 Rejecting neutral tumour evolution across human cancer types  — 2018  — ESMO Open  (Maxime Tarabichi)
Gene signature of the post-Chernobyl papillary thyroid cancer  — 2016  — European Journal of Nuclear Medicine and Molecular Imaging  (Vincent Detours)
Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome  — 2015  — Cell Reports  (Vincent Detours)
Intratumor heterogeneity and clonal evolution in an aggressive papillary thyroid cancer and matched metastases  — 2015  — Endocrine Related Cancer  (Maxime Tarabichi, Vincent Detours)
Comment on “Variation in cancer risk among tissues can be explained by the number of stem cell divisions”  — 2015  — bioRxiv (Cold Spring Harbor Laboratory) preprint  (Maxime Tarabichi, Vincent Detours)
Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and “swarm intelligence”  — 2013  — Cancer and Metastasis Reviews  (Maxime Tarabichi, Vincent Detours)
Comparative Analysis of the Thyrocytes and T Cells: Responses to H2O2 and Radiation Reveals an H2O2-Induced Antioxidant Transcriptional Program in Thyrocytes  — 2013  — The Journal of Clinical Endocrinology & Metabolism  (Maxime Tarabichi, Vincent Detours)
TriageTools: tools for partitioning and prioritizing analysis of high-throughput sequencing data  — 2013  — Nucleic Acids Research  (Vincent Detours)
Thyroid cancer cell lines: an overview  — 2012  — Frontiers in Endocrinology  (Maxime Tarabichi)
A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas  — 2012  — British Journal of Cancer  (Maxime Tarabichi, Vincent Detours)
Piecewise Polynomial Representations of Genomic Tracks  — 2012  — PLoS ONE  (Maxime Tarabichi, Vincent Detours)
Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome  — 2011  — PLoS Computational Biology  (Vincent Detours)
Gene Expression Profiles for Radiation-induced Thyroid Cancer  — 2011  — Clinical Oncology  (Vincent Detours)
Human cancer cell lines: Experimental models for cancer cells in situ? For cancer stem cells?  — 2009  — Biochimica et Biophysica Acta (BBA) - Reviews on Cancer  (Vincent Detours)
PP48 A proliferation measure integrates the outcome-related information contained in the breast cancer transcriptome  — 2009  — European Journal of Cancer Supplements  (Vincent Detours)
Gene expression profiles of post-Chernobyl thyroid cancers  — 2008  — Current Opinion in Endocrinology Diabetes and Obesity  (Vincent Detours)
Editorial comment should accompany hot papers online  — 2008  — Nature  (Vincent Detours)
Roles of Hydrogen Peroxide in Thyroid Physiology and Disease  — 2007  — The Journal of Clinical Endocrinology & Metabolism  (Vincent Detours)
Absence of a specific radiation signature in post-Chernobyl thyroid cancers  — 2005  — British Journal of Cancer  (Vincent Detours)
Gene expression in human thyrocytes and autonomous adenomas reveals suppression of negative feedbacks in tumorigenesis  — 2005  — Proceedings of the National Academy of Sciences  (Vincent Detours)
15 Systems biology, cell specificity, and physiology  — 2005  — Studies in multidisciplinarity  (Vincent Detours)
Prediction of proteasome cleavage motifs by neural networks  — 2002  — Protein Engineering Design and Selection  (Vincent Detours)
Evolutionary and immunological implications of contemporary HIV-1 variation  — 2001  — British Medical Bulletin  (Vincent Detours)
Deriving Quantitative Constraints on T Cell Selection from Data on the Mature T Cell Repertoire  — 2000  — The Journal of Immunology  (Vincent Detours)
The paradox of alloreactivity and self MHC restriction: Quantitative analysis and statistics  — 2000  — Proceedings of the National Academy of Sciences  (Vincent Detours)
A Quantitative Theory of Affinity-driven T Cell Repertoire Selection  — 1999  — Journal of Theoretical Biology  (Vincent Detours)
Explaining high alloreactivity as a quantitative consequence of affinity-driven thymocyte selection  — 1999  — Proceedings of the National Academy of Sciences  (Vincent Detours)
Pull off those price tags  — 1998  — Nature  (Vincent Detours)
Asynchrony Induces Stability in Cellular Automata Based Models  — 1994  — The MIT Press eBooks  (Vincent Detours)
Development of an Idiotypic Network in Shape Space  — 1994  — Journal of Theoretical Biology  (Vincent Detours)