Research
nan
Biography
Maxime studied engineering at the Faculty of Applied Sciences of the Université Libre de Bruxelles (ULB), where he specialised in medical informatics and imaging. He then pursued a PhD in computational biology under the supervision of Vincent Detours at the Faculty of Medicine (ULB), focusing on the integration of omics profiles in thyroid cancers. He later joined Peter Van Loo’s group at the Francis Crick Institute, where he studied intratumour genetic heterogeneity and cancer genome evolution, with a particular focus on rare sarcomas. During this time, he also visited Thierry Voet’s lab at the Wellcome Sanger Institute and developed expertise in single-cell sequencing. He is currently an Associate Professor and Group Leader at IRIBHM – ULB, as well as a visiting scientist at the MD Anderson Cancer Center and University College London. His lab investigates the somatic and cancer genome evolution of different tissues, including in the context of sarcomas and thyroid cancers.
Publications
The evolutionary history of 2,658 cancers
— Nature, 2020
Signatures of copy number alterations in human cancer
— Nature, 2022
A pan-cancer compendium of chromosomal instability
— Nature, 2022
A practical guide to cancer subclonal reconstruction from DNA sequencing
— Nature Methods, 2021
Thyroid cancer cell lines: an overview
— Frontiers in Endocrinology, 2012
Recurrent rearrangements of FOS and FOSB define osteoblastoma
— Nature Communications, 2018
A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas
— British Journal of Cancer, 2012
A general method to derive robust organ-specific gene expression-based differentiation indices: application to thyroid cancer diagnostic
— Oncogene, 2012
Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways
— Cancer Cell, 2019
MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution
— Genome biology, 2022
A community effort to create standards for evaluating tumor subclonal reconstruction
— Nature Biotechnology, 2020
Neutral tumor evolution?
— Nature Genetics, 2018
Revisiting the transcriptional analysis of primary tumours and associated nodal metastases with enhanced biological and statistical controls: application to thyroid cancer
— British Journal of Cancer, 2015
Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients
— Nature Communications, 2021
Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and “swarm intelligence”
— Cancer and Metastasis Reviews, 2013
Inferring structural variant cancer cell fraction
— Nature Communications, 2020
Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing
— Acta Neuropathologica Communications, 2019
Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
— Nature Communications, 2020
miRNA expression and function in thyroid carcinomas: a comparative and critical analysis and a model for other cancers
— Oncotarget, 2016
Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia
— Nature Cancer, 2021
Intratumor heterogeneity and clonal evolution in an aggressive papillary thyroid cancer and matched metastases
— Endocrine Related Cancer, 2015
Therapeutic vulnerability to PARP1,2 inhibition in RB1-mutant osteosarcoma
— Nature Communications, 2021
Drivers underpinning the malignant transformation of giant cell tumour of bone
— The Journal of Pathology, 2020
Aneuploidy and complex genomic rearrangements in cancer evolution
— Nature Cancer, 2024
Comparative Analysis of the Thyrocytes and T Cells: Responses to H2O2 and Radiation Reveals an H2O2-Induced Antioxidant Transcriptional Program in Thyrocytes
— The Journal of Clinical Endocrinology & Metabolism, 2013
Leveraging single‐cell sequencing to unravel intratumour heterogeneity and tumour evolution in human cancers
— The Journal of Pathology, 2022
Thyroid cancer under the scope of emerging technologies
— Molecular and Cellular Endocrinology, 2021
Distinctive Desmoplastic 3D Morphology Associated With BRAFV600E in Papillary Thyroid Cancers
— The Journal of Clinical Endocrinology & Metabolism, 2018
Characterizing Genetic Intra-Tumor Heterogeneity Across 2,658 Human Cancer Genomes
— SSRN Electronic Journal, 2020
Abstract 3000: Pervasive intra-tumour heterogeneity and subclonal selection across cancer types
— Cancer Research, 2018
A pan-cancer landscape of somatic mutations in non-unique regions of the human genome
— Nature Biotechnology, 2021
Creating Standards for Evaluating Tumour Subclonal Reconstruction
— bioRxiv (Cold Spring Harbor Laboratory), 2018
Genomic evolution shapes prostate cancer disease type
— Cell Genomics, 2024
Preclinical evaluation of CDK4 phosphorylation predicts high sensitivity of pleural mesotheliomas to CDK4 /6 inhibition
— Molecular Oncology, 2022
CDK4 phosphorylation status and rational use for combining CDK4/6 and BRAF/MEK inhibition in advanced thyroid carcinomas
— Frontiers in Endocrinology, 2023
Pervasive intra-tumour heterogeneity and subclonal selection across cancer types
— Cancer Research, 2018
Piecewise Polynomial Representations of Genomic Tracks
— PLoS ONE, 2012
Pan-cancer subclonal mutation analysis of 7,827 tumors predicts clinical outcome
— bioRxiv (Cold Spring Harbor Laboratory), 2024
Author Correction: The evolutionary history of 2,658 cancers
— Nature, 2023
A pan-cancer landscape of somatic substitutions in non-unique regions of the human genome
— bioRxiv (Cold Spring Harbor Laboratory), 2020
Comment on "Variation in cancer risk among tissues can be explained by the number of stem cell divisions"
— bioRxiv (Cold Spring Harbor Laboratory), 2015
The History of Chromosomal Instability in Genome-Doubled Tumors
— Cancer Discovery, 2024
Undifferentiated Sarcomas Develop Through Distinct Evolutionary Pathways
— SSRN Electronic Journal, 2018
Abstract 218: The evolutionary history of 2,658 cancers
— Cancer Research, 2018
Crowd-sourced benchmarking of single-sample tumour subclonal reconstruction
— bioRxiv (Cold Spring Harbor Laboratory), 2022
Preclinical evaluation of CDK4 phosphorylation predicts high sensitivity of malignant pleural mesotheliomas to CDK4/6 inhibition
— bioRxiv (Cold Spring Harbor Laboratory), 2022
