Research
Vincent's team work on various projects around different themes, including RNA editing in cancer; single-cell, spatial and bulk transcriptomics in breast, pancreatic and thyroid cancers; digital pathology of normal and cancer tissues; and understanding the spectrum of sexual differences.
Biography
After studying computer science and cognitive science, Vincent Detours earned a PhD in biology under the supervision of Francisco Varela in 1996. His research on biomathematical modeling of the immune system was conducted at the UniversitΓ© Libre de Bruxelles, the Santa Fe Institute, and the Theoretical Biology and Biophysics Division of Los Alamos National Laboratory (the birthplace of GenBank) in New Mexico. He is currently a researcher and professor in oncology and bioinformatics at the UniversitΓ© libre de Bruxelles.
Publications
Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome
β PLoS Computational Biology, 2011
Evolutionary and immunological implications of contemporary HIV-1 variation
β British Medical Bulletin, 2001
Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation
β Cell, 2018
Prediction of proteasome cleavage motifs by neural networks
β Protein Engineering Design and Selection, 2002
Clustering Patterns of Cytotoxic T-Lymphocyte Epitopes in Human Immunodeficiency Virus Type 1 (HIV-1) Proteins Reveal Imprints of Immune Evasion on HIV-1 Global Variation
β Journal of Virology, 2002
Roles of Hydrogen Peroxide in Thyroid Physiology and Disease
β The Journal of Clinical Endocrinology & Metabolism, 2007
Human cancer cell lines: Experimental models for cancer cells in situ? For cancer stem cells?
β Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2009
Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome
β Cell Reports, 2015
A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas
β British Journal of Cancer, 2012
Human Thyroid Tumor Cell Lines Derived from Different Tumor Types Present a Common Dedifferentiated Phenotype
β Cancer Research, 2007
Asynchrony Induces Stability in Cellular Automata Based Models
β The MIT Press eBooks, 1994
A general method to derive robust organ-specific gene expression-based differentiation indices: application to thyroid cancer diagnostic
β Oncogene, 2012
Immune Checkpoint Molecules on Tumor-Infiltrating Lymphocytes and Their Association with Tertiary Lymphoid Structures in Human Breast Cancer
β Frontiers in Immunology, 2017
Gene expression and the biological phenotype of papillary thyroid carcinomas
β Oncogene, 2007
Genes Expressed in Specific Areas of the Human Fetal Cerebral Cortex Display Distinct Patterns of Evolution
β PLoS ONE, 2011
Genome-wide gene expression profiling suggests distinct radiation susceptibilities in sporadic and post-Chernobyl papillary thyroid cancers
β British Journal of Cancer, 2007
Gene signature of the post-Chernobyl papillary thyroid cancer
β European Journal of Nuclear Medicine and Molecular Imaging, 2016
Gene expression in human thyrocytes and autonomous adenomas reveals suppression of negative feedbacks in tumorigenesis
β Proceedings of the National Academy of Sciences, 2005
Absence of a specific radiation signature in post-Chernobyl thyroid cancers
β British Journal of Cancer, 2005
Revisiting the transcriptional analysis of primary tumours and associated nodal metastases with enhanced biological and statistical controls: application to thyroid cancer
β British Journal of Cancer, 2015
New global analysis of the microRNA transcriptome of primary tumors and lymph node metastases of papillary thyroid cancer
β BMC Genomics, 2015
Transfer of clinically relevant gene expression signatures in breast cancer: from Affymetrix microarray to Illumina RNA-Sequencing technology
β BMC Genomics, 2014
Hominin-specific NOTCH2 paralogs expand human cortical neurogenesis through regulation of Delta/Notch interactions
β bioRxiv (Cold Spring Harbor Laboratory), 2017
A Quantitative Theory of Affinity-driven T Cell Repertoire Selection
β Journal of Theoretical Biology, 1999
Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and βswarm intelligenceβ
β Cancer and Metastasis Reviews, 2013
InSilico DB genomic datasets hub: an efficient starting point for analyzing genome-wide studies in GenePattern, Integrative Genomics Viewer, and R/Bioconductor
β Genome biology, 2012
BRCA gene mutations do not shape the extent and organization of tumor infiltrating lymphocytes in triple negative breast cancer
β Cancer Letters, 2019
Transcriptional output, cell-type densities, and normalization in spatial transcriptomics
β Journal of Molecular Cell Biology, 2020
Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism
β Nature Communications, 2022
Development of an Idiotypic Network in Shape Space
β Journal of Theoretical Biology, 1994
Explaining high alloreactivity as a quantitative consequence of affinity-driven thymocyte selection
β Proceedings of the National Academy of Sciences, 1999
miRNA expression and function in thyroid carcinomas: a comparative and critical analysis and a model for other cancers
β Oncotarget, 2016
Singleβcell transcriptome analysis reveals thyrocyte diversity in the zebrafish thyroid gland
β EMBO Reports, 2020
Integration and crossβvalidation of highβthroughput gene expression data: comparing heterogeneous data sets
β FEBS Letters, 2003
Deriving Quantitative Constraints on T Cell Selection from Data on the Mature T Cell Repertoire
β The Journal of Immunology, 2000
Intratumor heterogeneity and clonal evolution in an aggressive papillary thyroid cancer and matched metastases
β Endocrine Related Cancer, 2015
Gene Expression Profiles for Radiation-induced Thyroid Cancer
β Clinical Oncology, 2011
Size and Connectivity of the Idiotypic Network Are Independent of the Discreteness of the Affinity Distribution
β Journal of Theoretical Biology, 1996
Fluorescent Multiplex Immunohistochemistry Coupled With Other State-Of-The-Art Techniques to Systematically Characterize the Tumor Immune Microenvironment
β Frontiers in Molecular Biosciences, 2021
Gene expression in thyroid autonomous adenomas provides insight into their physiopathology
β Oncogene, 2005
The paradox of alloreactivity and self MHC restriction: Quantitative analysis and statistics
β Proceedings of the National Academy of Sciences, 2000
Gene Expression in RET/PTC3 and E7 Transgenic Mouse Thyroids: RET/PTC3 But Not E7 Tumors Are Partial and Transient Models of Human Papillary Thyroid Cancers
β Endocrinology, 2008
Comparative Analysis of the Thyrocytes and T Cells: Responses to H2O2 and Radiation Reveals an H2O2-Induced Antioxidant Transcriptional Program in Thyrocytes
β The Journal of Clinical Endocrinology & Metabolism, 2013
Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids
β Oncogene, 2023
No significant viral transcription detected in whole breast cancer transcriptomes
β BMC Cancer, 2015
A Measure of the Signal-to-Noise Ratio of Microarray Samples and Studies Using Gene Correlations
β PLoS ONE, 2012
Thyroid cancer under the scope of emerging technologies
β Molecular and Cellular Endocrinology, 2021
Factors contributing to the resistance of the thyrocyte to hydrogen peroxide
β Molecular and Cellular Endocrinology, 2018
Distinctive Desmoplastic 3D Morphology Associated With BRAFV600E in Papillary Thyroid Cancers
β The Journal of Clinical Endocrinology & Metabolism, 2018
Gene expression profiles of post-Chernobyl thyroid cancers
β Current Opinion in Endocrinology Diabetes and Obesity, 2008
Transcriptional output, cell types densities and normalization in spatial transcriptomics
β bioRxiv (Cold Spring Harbor Laboratory), 2018
TriageTools: tools for partitioning and prioritizing analysis of high-throughput sequencing data
β Nucleic Acids Research, 2013
Principles governing A-to-I RNA editing in the breast cancer transcriptome
β bioRxiv (Cold Spring Harbor Laboratory), 2014
Dissecting the Role of Thyrotropin in the DNA Damage Response in Human Thyrocytes after 131I, Ξ³ Radiation and H2O2
β The Journal of Clinical Endocrinology & Metabolism, 2019
Negative Feedbacks in Normal Cell Growth and Their Suppression in Tumorigenesis
β Cell Cycle, 2006
Piecewise Polynomial Representations of Genomic Tracks
β PLoS ONE, 2012
Comment on "Variation in cancer risk among tissues can be explained by the number of stem cell divisions"
β bioRxiv (Cold Spring Harbor Laboratory), 2015
Editorial comment should accompany hot papers online
β Nature, 2008
Dual targeting of MAPK and PI3K pathways unlocks redifferentiation ofBraf-mutated thyroid cancer organoids
β bioRxiv (Cold Spring Harbor Laboratory), 2023
Favorable histo-molecular remodeling of pancreatic ductal adenocarcinoma after Total Neoadjuvant Therapy including Stereotactic Body Radiotherapy
β bioRxiv (Cold Spring Harbor Laboratory), 2024
Single nuclei and spatial transcriptomes suggest a stratification of papillary and anaplastic thyroid cancer cells
β bioRxiv (Cold Spring Harbor Laboratory), 2024
