Research
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Biography
Après avoir étudié l'informatique et les sciences cognitives, Vincent Detours obtient un doctorat en biologie sous la direction de Francisco Varela en 1996. Ses travaux sur la modélisation biomathématique du système immunitaire furent conduits à l'Université libre de Bruxelles, à l'Institut de Santa Fe et à la division de biologie théorique et biophysique du Laboratoire national de Los Alamos (le berceau de GenBank) au Nouveau-Mexique. Il est actuellement chercheur et professeur en oncologie et bio-informatique à l'Université libre de Bruxelles.
Publications
Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome
— PLoS Computational Biology, 2011
Evolutionary and immunological implications of contemporary HIV-1 variation
— British Medical Bulletin, 2001
Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation
— Cell, 2018
Prediction of proteasome cleavage motifs by neural networks
— Protein Engineering Design and Selection, 2002
Clustering Patterns of Cytotoxic T-Lymphocyte Epitopes in Human Immunodeficiency Virus Type 1 (HIV-1) Proteins Reveal Imprints of Immune Evasion on HIV-1 Global Variation
— Journal of Virology, 2002
Roles of Hydrogen Peroxide in Thyroid Physiology and Disease
— The Journal of Clinical Endocrinology & Metabolism, 2007
Human cancer cell lines: Experimental models for cancer cells in situ? For cancer stem cells?
— Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2009
Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome
— Cell Reports, 2015
A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas
— British Journal of Cancer, 2012
Human Thyroid Tumor Cell Lines Derived from Different Tumor Types Present a Common Dedifferentiated Phenotype
— Cancer Research, 2007
Asynchrony Induces Stability in Cellular Automata Based Models
— The MIT Press eBooks, 1994
A general method to derive robust organ-specific gene expression-based differentiation indices: application to thyroid cancer diagnostic
— Oncogene, 2012
Immune Checkpoint Molecules on Tumor-Infiltrating Lymphocytes and Their Association with Tertiary Lymphoid Structures in Human Breast Cancer
— Frontiers in Immunology, 2017
Genes Expressed in Specific Areas of the Human Fetal Cerebral Cortex Display Distinct Patterns of Evolution
— PLoS ONE, 2011
Genome-wide gene expression profiling suggests distinct radiation susceptibilities in sporadic and post-Chernobyl papillary thyroid cancers
— British Journal of Cancer, 2007
Gene signature of the post-Chernobyl papillary thyroid cancer
— European Journal of Nuclear Medicine and Molecular Imaging, 2016
Absence of a specific radiation signature in post-Chernobyl thyroid cancers
— British Journal of Cancer, 2005
Gene expression in human thyrocytes and autonomous adenomas reveals suppression of negative feedbacks in tumorigenesis
— Proceedings of the National Academy of Sciences, 2005
Revisiting the transcriptional analysis of primary tumours and associated nodal metastases with enhanced biological and statistical controls: application to thyroid cancer
— British Journal of Cancer, 2015
New global analysis of the microRNA transcriptome of primary tumors and lymph node metastases of papillary thyroid cancer
— BMC Genomics, 2015
Transfer of clinically relevant gene expression signatures in breast cancer: from Affymetrix microarray to Illumina RNA-Sequencing technology
— BMC Genomics, 2014
Hominin-specific NOTCH2 paralogs expand human cortical neurogenesis through regulation of Delta/Notch interactions
— bioRxiv (Cold Spring Harbor Laboratory), 2017
A Quantitative Theory of Affinity-driven T Cell Repertoire Selection
— Journal of Theoretical Biology, 1999
Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and “swarm intelligence”
— Cancer and Metastasis Reviews, 2013
InSilico DB genomic datasets hub: an efficient starting point for analyzing genome-wide studies in GenePattern, Integrative Genomics Viewer, and R/Bioconductor
— Genome biology, 2012
Transcriptional output, cell-type densities, and normalization in spatial transcriptomics
— Journal of Molecular Cell Biology, 2020
Development of an Idiotypic Network in Shape Space
— Journal of Theoretical Biology, 1994
Explaining high alloreactivity as a quantitative consequence of affinity-driven thymocyte selection
— Proceedings of the National Academy of Sciences, 1999
BRCA gene mutations do not shape the extent and organization of tumor infiltrating lymphocytes in triple negative breast cancer
— Cancer Letters, 2019
miRNA expression and function in thyroid carcinomas: a comparative and critical analysis and a model for other cancers
— Oncotarget, 2016
Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism
— Nature Communications, 2022
Integration and cross‐validation of high‐throughput gene expression data: comparing heterogeneous data sets
— FEBS Letters, 2003
Single‐cell transcriptome analysis reveals thyrocyte diversity in the zebrafish thyroid gland
— EMBO Reports, 2020
Deriving Quantitative Constraints on T Cell Selection from Data on the Mature T Cell Repertoire
— The Journal of Immunology, 2000
Intratumor heterogeneity and clonal evolution in an aggressive papillary thyroid cancer and matched metastases
— Endocrine Related Cancer, 2015
Gene Expression Profiles for Radiation-induced Thyroid Cancer
— Clinical Oncology, 2011
Size and Connectivity of the Idiotypic Network Are Independent of the Discreteness of the Affinity Distribution
— Journal of Theoretical Biology, 1996
Fluorescent Multiplex Immunohistochemistry Coupled With Other State-Of-The-Art Techniques to Systematically Characterize the Tumor Immune Microenvironment
— Frontiers in Molecular Biosciences, 2021
Gene expression in thyroid autonomous adenomas provides insight into their physiopathology
— Oncogene, 2005
Gene Expression in RET/PTC3 and E7 Transgenic Mouse Thyroids: RET/PTC3 But Not E7 Tumors Are Partial and Transient Models of Human Papillary Thyroid Cancers
— Endocrinology, 2008
The paradox of alloreactivity and self MHC restriction: Quantitative analysis and statistics
— Proceedings of the National Academy of Sciences, 2000
Comparative Analysis of the Thyrocytes and T Cells: Responses to H2O2 and Radiation Reveals an H2O2-Induced Antioxidant Transcriptional Program in Thyrocytes
— The Journal of Clinical Endocrinology & Metabolism, 2013
No significant viral transcription detected in whole breast cancer transcriptomes
— BMC Cancer, 2015
A Measure of the Signal-to-Noise Ratio of Microarray Samples and Studies Using Gene Correlations
— PLoS ONE, 2012
Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids
— Oncogene, 2023
Thyroid cancer under the scope of emerging technologies
— Molecular and Cellular Endocrinology, 2021
Distinctive Desmoplastic 3D Morphology Associated With BRAFV600E in Papillary Thyroid Cancers
— The Journal of Clinical Endocrinology & Metabolism, 2018
Factors contributing to the resistance of the thyrocyte to hydrogen peroxide
— Molecular and Cellular Endocrinology, 2018
Gene expression profiles of post-Chernobyl thyroid cancers
— Current Opinion in Endocrinology Diabetes and Obesity, 2008
Transcriptional output, cell types densities and normalization in spatial transcriptomics
— bioRxiv (Cold Spring Harbor Laboratory), 2018
TriageTools: tools for partitioning and prioritizing analysis of high-throughput sequencing data
— Nucleic Acids Research, 2013
Dissecting the Role of Thyrotropin in the DNA Damage Response in Human Thyrocytes after 131I, γ Radiation and H2O2
— The Journal of Clinical Endocrinology & Metabolism, 2019
Principles governing A-to-I RNA editing in the breast cancer transcriptome
— bioRxiv (Cold Spring Harbor Laboratory), 2014
Piecewise Polynomial Representations of Genomic Tracks
— PLoS ONE, 2012
Comment on "Variation in cancer risk among tissues can be explained by the number of stem cell divisions"
— bioRxiv (Cold Spring Harbor Laboratory), 2015
Editorial comment should accompany hot papers online
— Nature, 2008
Dual targeting of MAPK and PI3K pathways unlocks redifferentiation ofBraf-mutated thyroid cancer organoids
— bioRxiv (Cold Spring Harbor Laboratory), 2023
